HIV-1-based defective lentiviral vectors efficiently transduce human monocytes-derived macrophages and suppress replication of wild-type HIV-1.

@article{Zeng2006HIV1basedDL,
  title={HIV-1-based defective lentiviral vectors efficiently transduce human monocytes-derived macrophages and suppress replication of wild-type HIV-1.},
  author={Lingbing Zeng and Vicente Planelles and Ziye Sui and Suzanne Gartner and Sanjay B. Maggirwar and Stephen Dewhurst and Linbai Ye and Vivek R Nerurkar and Richard Yanagihara and Yuanan Lu},
  journal={The journal of gene medicine},
  year={2006},
  volume={8 1},
  pages={
          18-28
        }
}
BACKGROUND Human monocytes play an important role in mediating human immunodeficiency virus type 1 (HIV-1) infection of the central nervous system (CNS), and monocytes-derived macrophages (MDM) represent a major viral reservoir within the brain and other target organs. Current gene transduction of MDM is hindered by a limited efficiency. In this study we established a lentiviral vector-based technique for improved gene transfer into human MDM cultures in vitro and demonstrated significant… CONTINUE READING

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