HIV-1 and the aetiology of AIDS

  title={HIV-1 and the aetiology of AIDS},
  author={Martin T Schechter and Kevin J. P. Craib and Julio S. G. Montaner and T. N. Le and Michael V. O’Shaughnessy and Karen A. Gelmon},
  journal={The Lancet},
The belief that HIV-1 infection causes AIDs has been questioned, and the suggestion made that to know the correct cause of AIDS the incidence of disease in patients with and without risk behaviours and with and without antibody to HIV-1 must be known. We describe findings in such a cohort. In 715 homosexual men followed for a median of 8.6 years, all 136 AIDS cases occurred in the 365 individuals with pre-existing HIV-1 antibody. Most men negative for HIV-1 antibody reported risk behaviours but… Expand
HIV causes AIDS: Koch's postulates fulfilled.
The spread of AIDS through sexual contact, blood transfusion and contaminated syringes has led to a recent estimate of nearly four million AIDS cases worldwide and some 21 million people infected with HIV-1 or HIV-2. Expand
HIV, AIDS, and the distortion of science.
The denialist view— based as it is on the distortion of science— is fundamentally dangerous, since it sets the stage for another wave of transmission and death. Expand
How much longer can we afford the AIDS virus monopoly
Until 1984 AIDS science was open. Initially the new epidemic of pneumonias and Kaposi’s sarcomas, since called AIDS, was considered a collection of non-infectious ‘lifestyle’ diseases. But theExpand
How does HIV cause AIDS
Overall, it is increasingly evident that both the tropism and burden of HIV infection correlate closely with the manifestations of disease. Expand
Estimation of the size and characteristics of HIV-positive populations in Europe
A method based on an individual-based progression model of HIV and the effect of ART to reconstruct and hence better understand the HIV-positive population, for use in Europe is developed. Expand
The chemical bases of the various AIDS epidemics: Recreational drugs, anti-viral chemotherapy and malnutrition
It is proposed that AIDS is a collection of chemical epidemics, caused by recreational drugs, anti-HIV drugs, and malnutrition, and is predicted to predict AIDS prevention by adequate nutrition and abstaining from Drugs, and even cures by treating AIDS diseases with proven medications. Expand
HIV-specific cytotoxic T-cells in HIV-exposed but uninfected Gambian women
This work has identified four HIV-1 and HIV-2 cross-reactive peptide epitopes, presented to CTL from HIV-infected Gambians by HLA-B35 (the most common Gambian class I HLA molecule), which may represent protective immunity against HIV infection. Expand
AIDS Denialism and Public Health Practice
It is shown how statistics on mortality and indices such as crude death rate, life expectancy, child mortality, and population growth are consistent with the high mortality from AIDS, and the weakness of statistics from death notification, quoted by denialists are exposed. Expand
The solution to the seven mysteries of AIDS: the 'Trojan horse'.
It is concluded that the sperm is the cause of AIDS but that HIV may slightly alter the symptoms of this disease, as compared to idiopathic CD4+ T-lymphocytopenia, or ICL, where the sperm, but notExpand
The AIDS dilemma: drug diseases blamed on a passenger virus
It is proposed that the long-term consumption of recreational drugs and prescriptions of DNA chain-terminating and other anti-HIV drugs, cause all AIDS diseases in America and Europe that exceed their long-established, national backgrounds, i.e. <95%. Expand


AIDS epidemiology: inconsistencies with human immunodeficiency virus and with infectious disease.
  • P. Duesberg
  • Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 1991
It was concluded that American AIDS is not infectious, and it was suggested that unidentified, mostly noninfectious pathogens cause AIDS. Expand
Human immunodeficiency virus and acquired immunodeficiency syndrome: correlation but not causation.
  • P. Duesberg
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 1989
HIV is not sufficient for AIDS and that it may not even be necessary for AIDS because its activity is just as low in symptomatic carriers as in asymptomatic carriers, and the correlation between antibody to HIV and AIDS does not prove causation. Expand
The human immunodeficiency virus: infectivity and mechanisms of pathogenesis.
Infection with the human immunodeficiency virus (HIV) results in a profound immunosuppression due predominantly to a selective depletion of helper/inducer T lymphocytes that express the receptor forExpand
Low HIV‐1 proviral DNA burden detected by negative polymerase chain reaction in seropositive individuals correlates with slower disease progression
It is concluded that PCR can identify a group of HIV-infected people with very low levels of proviral DNA who demonstrate slower progression of the effects of HIV. Expand
Retroviruses as carcinogens and pathogens: expectations and reality.
It has been proposed that retroviruses transform inefficiently by activating latent cellular oncogenes by for example provirus integration, which predicts diploid tumors with great diversity, because integration sites are different in each tumor. Expand