HIV-1 adaptation to NK cell-mediated immune pressure

  title={HIV-1 adaptation to NK cell-mediated immune pressure},
  author={Marjet Elemans and Lies Boelen and Michael Rasmussen and S{\o}ren Buus and Becca Asquith},
  booktitle={PLoS pathogens},
The observation, by Alter et al., of the enrichment of NK cell "escape" variants in individuals carrying certain Killer-cell Immunoglobulin-like Receptor (KIR) genes is compelling evidence that natural killer (NK) cells exert selection pressure on HIV-1. Alter et al hypothesise that variant peptide, in complex with HLA class I molecules binds KIR receptors and either increases NK cell inhibition or decreases NK cell activation compared to wild type peptide thus leading to virus escape from the… CONTINUE READING
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Selection of an HLAC * 03 : 04Restricted HIV - 1 p 24 Gag Sequence Variant Is Associated with Viral Escape from KIR 2 DL 3 + Natural Killer Cells : Data from an Observational Cohort in South Africa

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