HIV-1 Vpr increases viral expression by manipulation of the cell cycle: A mechanism for selection of Vpr in vivo

@article{Goh1998HIV1VI,
  title={HIV-1 Vpr increases viral expression by manipulation of the cell cycle: A mechanism for selection of Vpr in vivo},
  author={Wei Chun Goh and Mark E. Rogel and C Matthew Kinsey and Scott F. Michael and Patricia N. Fultz and Martin A. Nowak and Beatrice H. Hahn and Michael Emerman},
  journal={Nature Medicine},
  year={1998},
  volume={4},
  pages={65-71}
}
The human immunodeficiency virus type 1 (HIV-1) encodes a protein, called Vpr, that prevents proliferation of infected cells by arresting them in G2 of the cell cycle. This Vpr-mediated cell-cycle arrest is also conserved among highly divergent simian immunodeficiency viruses, suggesting an important role in the virus life cycle. However, it has been unclear how this could be a selective advantage for the virus. Here we provide evidence that expression of the viral genome is optimal in the G2… CONTINUE READING