HIV-1 Vpr increases viral expression by manipulation of the cell cycle: A mechanism for selection of Vpr in vivo

@article{Goh1998HIV1VI,
  title={HIV-1 Vpr increases viral expression by manipulation of the cell cycle: A mechanism for selection of Vpr in vivo},
  author={W. C. Goh and M. Rogel and C. M. Kinsey and S. Michael and P. Fultz and M. Nowak and B. Hahn and M. Emerman},
  journal={Nature Medicine},
  year={1998},
  volume={4},
  pages={65-71}
}
  • W. C. Goh, M. Rogel, +5 authors M. Emerman
  • Published 1998
  • Biology, Medicine
  • Nature Medicine
  • The human immunodeficiency virus type 1 (HIV-1) encodes a protein, called Vpr, that prevents proliferation of infected cells by arresting them in G2 of the cell cycle. This Vpr-mediated cell-cycle arrest is also conserved among highly divergent simian immunodeficiency viruses, suggesting an important role in the virus life cycle. However, it has been unclear how this could be a selective advantage for the virus. Here we provide evidence that expression of the viral genome is optimal in the G2… CONTINUE READING
    The HIV-1 Vif protein mediates degradation of Vpr and reduces Vpr-induced cell cycle arrest.
    22
    Vpr-Host Interactions During HIV-1 Viral Life Cycle
    46
    HIV-1 Vpr Accelerates Viral Replication during Acute Infection by Exploitation of Proliferating CD4+ T Cells In Vivo
    42
    Viral protein R of HIV-1.
    101

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 39 REFERENCES