HIV-1 Vpr activates the DNA damage response in renal tubule epithelial cells.

Abstract

HIV-associated nephropathy (HIVAN) is a major cause of HIV-related morbidity and mortality. Pathogenesis involves direct infection of the glomerular and tubular epithelial cells leading to characteristic disorder. Recently, we have shown that HIV-1 Vpr causes hypertrophy, hyperploidy, and apoptosis. Here, we report that Vpr activates the DNA damage response… (More)
DOI: 10.1097/QAD.0b013e32833088a0

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