HIV-1 Vpr Protein Induces Proteasomal Degradation of Chromatin-associated Class I HDACs to Overcome Latent Infection of Macrophages.

@article{Romani2016HIV1VP,
  title={HIV-1 Vpr Protein Induces Proteasomal Degradation of Chromatin-associated Class I HDACs to Overcome Latent Infection of Macrophages.},
  author={Bizhan Romani and Nima Shaykh Baygloo and Mojtaba Hamidi-Fard and Mohammad Reza Aghasadeghi and Elham Allahbakhshi},
  journal={The Journal of biological chemistry},
  year={2016},
  volume={291 6},
  pages={2696-711}
}
Mechanisms underlying HIV-1 latency remain among the most crucial questions that need to be answered to adopt strategies for purging the latent viral reservoirs. Here we show that HIV-1 accessory protein Vpr induces depletion of class I HDACs, including HDAC1, 2, 3, and 8, to overcome latency in macrophages. We found that Vpr binds and depletes chromatin-associated class I HDACs through a VprBP-dependent mechanism, with HDAC3 as the most affected class I HDAC. De novo expression of Vpr in… CONTINUE READING
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