HIV-1 Vpr: a novel role in regulating RNA splicing.

@article{Zhang2009HIV1VA,
  title={HIV-1 Vpr: a novel role in regulating RNA splicing.},
  author={Xianfeng Zhang and Yoko Aida},
  journal={Current HIV research},
  year={2009},
  volume={7 2},
  pages={
          163-8
        }
}
Pre-mRNA splicing is a critical step in gene expression for metazoans. Several viral proteins regulate the splicing of pre-mRNAs through complex interactions with the host cell RNA splicing machinery. Here, we focus on a novel function of HIV-1 Vpr, which selectively inhibits cellular and viral pre-mRNA splicing via interactions with components of the spliceosome complex. This review discusses our current knowledge of how RNA splicing regulation is accomplished by Vpr-host factor interactions. 
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Use of HIV as a gene transfer vector.
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