HIV-1 Tat protein enhances Microtubule polymerization

  title={HIV-1 Tat protein enhances Microtubule polymerization},
  author={Jean de Mareuil and Manon Carr{\'e} and Pascale Barbier and Grant R. Campbell and Sophie Lancelot and Sandrine Opi and Didier Esquieu and Jennifer D. Watkins and Charles Pr{\'e}v{\^o}t and Diane Braguer and Vincent Peyrot and Erwann P. Loret},
  pages={5 - 5}
HIV infection and progression to AIDS is characterized by the depletion of T cells, which could be due, in part, to apoptosis mediated by the extra-cellular HIV-encoded Tat protein as a consequence of Tat binding to tubulin. Microtubules are tubulin polymers that are essential for cell structure and division. Molecules that target microtubules induce apoptosis and are potent anti-cancer drugs. We studied the effect on tubulin polymerization of three Tat variants: Tat HxB2 and Tat Eli from… CONTINUE READING
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The Peptide. In Solid phase peptide synthesis Volume 2

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Highly Influential
3 Excerpts

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