HIV-1 Tat protein and endothelium: From protein/cell interaction to AIDS-associated pathologies

@article{Rusnati2002HIV1TP,
  title={HIV-1 Tat protein and endothelium: From protein/cell interaction to AIDS-associated pathologies},
  author={Marco Rusnati and Marco Presta},
  journal={Angiogenesis},
  year={2002},
  volume={5},
  pages={141-151}
}
Tat protein, the transactivating factor of the human immunodeficiency virus type 1 (HIV-1), is a small cationic polypeptide that can be released from HIV-1 infected cells. Extracellular Tat elicits different biological responses in several types of target cells, including endothelial cells (ECs). In the present paper, we will review the various aspects from the laboratory bench to the bedside that characterize the tight relationship that exists between HIV-1 Tat and the endothelium. Tat… CONTINUE READING