HIV-1 Tat promotes monocyte chemoattractant protein-1 secretion followed by transmigration of monocytes.

@article{Park2001HIV1TP,
  title={HIV-1 Tat promotes monocyte chemoattractant protein-1 secretion followed by transmigration of monocytes.},
  author={Iha Park and Jian Fei Wang and JeromeE. Groopman},
  journal={Blood},
  year={2001},
  volume={97 2},
  pages={
          352-8
        }
}
The mechanism whereby HIV-infected cells transit from the bloodstream into tissues is not well defined. This phenomenon was addressed by studying the effects of HIV-1 Tat, a protein secreted by infected cells, on human lung microvascular endothelial cells (HMVEC-Ls). It was found that monocyte chemoattractant protein-1 (MCP-1) was released from HMVEC-Ls in a dose- and time-dependent manner after Tat treatment. MCP-1 is a potent beta-chemokine that recruits monocytes and T cells and promotes… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 63 CITATIONS, ESTIMATED 72% COVERAGE

The Role of Macrophages in HIV-1 Persistence and Pathogenesis

VIEW 11 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

HIV-1 Tat protein and endothelium: From protein/cell interaction to AIDS-associated pathologies

VIEW 7 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Cocaine-induced release of CXCL10 from pericytes regulates monocyte transmigration into the CNS

VIEW 1 EXCERPT
CITES BACKGROUND

FILTER CITATIONS BY YEAR

2000
2020

CITATION STATISTICS

  • 4 Highly Influenced Citations