HIV-1 Tat modulates T-bet expression and induces Th1 type of immune response.

@article{Kulkarni2005HIV1TM,
  title={HIV-1 Tat modulates T-bet expression and induces Th1 type of immune response.},
  author={Asavari Kulkarni and Dyavar S Ravi and Kamini Singh and Shravanti Rampalli and Vrajesh V. Parekh and Debashis Mitra and Samit Chattopadhyay},
  journal={Biochemical and biophysical research communications},
  year={2005},
  volume={329 2},
  pages={706-12}
}
The HIV-1 transactivator Tat performs various viral and cellular functions. Primarily, it induces processive transcription from the HIV-1 LTR promoter. However, Tat secreted from infected cells is known to activate uninfected lymphocytes through receptors. To further delineate the specific target genes, extracellular Tat was expressed on the cell membrane of stimulator cells and co-cultured with human PBMCs. Along with induced CD4(+) T cell proliferation and IFN-gamma secretion, there was… CONTINUE READING