HIV-1 Tat Triggers TGF-β Production and NK Cell Apoptosis that is Prevented by Pertussis Toxin B

@article{Poggi2006HIV1TT,
  title={HIV-1 Tat Triggers TGF-β Production and NK Cell Apoptosis that is Prevented by Pertussis Toxin B},
  author={Alessandro Poggi and Maria Raffaella Zocchi},
  journal={Clinical and Developmental Immunology},
  year={2006},
  volume={13},
  pages={369 - 372}
}
Herein, we show that PTX-B and its non-toxic mutant PT9K/129G inhibit transcription and secretion of TGF-beta elicited by HIV-1 Tat in NK cells. Moreover, Tat strongly activates the cJun component of the multimolecular complex AP-1, while TGF-beta triggers cFos and cJun. Treatment of NK cells In turn,with PTX-B or PT9K/129G inhibits Tat and TGF-beta-induced activation of AP-1. TGF-beta enhances starvation-induced NK cell apoptosis, reduces the transcription of the antiapoptotic protein Bcl-2… CONTINUE READING
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Pronounced acute immunosuppression in vivo mediated by HIV Tat challenge.

Proceedings of the National Academy of Sciences of the United States of America • 1999
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