HIV-1 Tat Molecular Diversity and Induction of TNF-α: Implications for HIV-Induced Neurological Disease

@article{Mayne1998HIV1TM,
  title={HIV-1 Tat Molecular Diversity and Induction of TNF-$\alpha$: Implications for HIV-Induced Neurological Disease},
  author={Michael B. Mayne and Ana Christina Bratanich and Peiqin Chen and Farazana Rana and Avindra Nath and Christopher Power},
  journal={Neuroimmunomodulation},
  year={1998},
  volume={5},
  pages={184 - 192}
}
Activation and infection by HIV-1 of glial cells and infiltrating macrophages are cardinal features of AIDS-related neurological disease. Tumor necrosis factor-α (TNF-α) is released by these cell types, and increased TNF-α mRNA and protein levels are associated with the development and severity of HIV-induced neurological disease. HIV-1 proteins have been implicated in HIV neuropathogenesis including Tat which has been shown to be a potent inducer of TNF-α. We review our data showing the… 

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