HIV-1 Tat C-mediated regulation of tumor necrosis factor receptor-associated factor-3 by microRNA 32 in human microglia

@inproceedings{Mishra2012HIV1TC,
  title={HIV-1 Tat C-mediated regulation of tumor necrosis factor receptor-associated factor-3 by microRNA 32 in human microglia},
  author={Ritu Mishra and Chintan Chhatbar and Sunit K Singh},
  booktitle={Journal of Neuroinflammation},
  year={2012}
}
BackgroundHIV-1 Tat protein is known to be associated with neuroinflammation, a condition that develops in almost half of patients infected with HIV-1. HIV-1 Tat can alter glial neuroprotective functions, leading to neurotoxicity within the CNS. HIV-1 Tat is known to be secreted from productively infected cells and can affect neighboring uninfected cells by modulating cellular gene expression in a bystander fashion.MethodsWe were interested to study whether exogenous exposure to HIV-1 Tat-C… CONTINUE READING

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