HIV-1 TAT inhibits microglial phagocytosis of Abeta peptide.

@article{Giunta2008HIV1TI,
  title={HIV-1 TAT inhibits microglial phagocytosis of Abeta peptide.},
  author={Brian Nelson Giunta and Yuyan Zhou and Huayan Hou and Elona Rrapo and Francisco Miguel Lucas Fern{\'a}ndez and Jun Tan},
  journal={International journal of clinical and experimental pathology},
  year={2008},
  volume={1 3},
  pages={
          260-75
        }
}
Human immunodeficiency virus (HIV)-associated dementia (HAD) is a subcortical neuropsychiatric syndrome that has increased in prevalence in the era of highly active antiretroviral therapy (HAART). Several studies demonstrated increased amyloidosis in brains of HIV patients and suggested that there may be a significant number of long-term HIV survivors with co-morbid Alzheimer's disease (AD) in the future. We show HIV-1 Tat protein inhibits microglial uptake of Abeta1-42 peptide, a process that… CONTINUE READING

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