HIV-1 TAR RNA: the target of molecular interactions between the virus and its host.

@article{Bannwarth2005HIV1TR,
  title={HIV-1 TAR RNA: the target of molecular interactions between the virus and its host.},
  author={Sylvie Bannwarth and Anne Gatignol},
  journal={Current HIV research},
  year={2005},
  volume={3 1},
  pages={61-71}
}
HIV-1 TAR RNA is the binding site of the viral protein Tat, the trans-activator of the HIV-1 LTR. It is present at the 5' end of all HIV-1 spliced and unspliced mRNAs in the nucleus as well as in the cytoplasm. It has a highly folded stem-bulge-loop structure, which also binds cellular proteins to form ribonucleoprotein complexes. The Tat-Cyclin T1-CDK9 complex is the main component in the trans-activation of HIV-1 and its affinity for TAR is regulated through Tat acetylation by histone acetyl… CONTINUE READING

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