HIV-1-Specific CD8 T Cells Exhibit Limited Cross-Reactivity during Acute Infection.

@article{Du2016HIV1SpecificCT,
  title={HIV-1-Specific CD8 T Cells Exhibit Limited Cross-Reactivity during Acute Infection.},
  author={Victor Yimin Du and Anju Bansal and Jonathan M. Carlson and Jesus F Salazar-Gonzalez and Maria G Salazar and Kristin Ladell and Stephanie Gras and Tracy Maree Josephs and Sonya L Heath and David A Price and Jamie Rossjohn and Eric Hunter and Paul A Goepfert},
  journal={Journal of immunology},
  year={2016},
  volume={196 8},
  pages={
          3276-86
        }
}
Prior work has demonstrated that HIV-1-specific CD8 T cells can cross-recognize variant epitopes. However, most of these studies were performed in the context of chronic infection, where the presence of viral quasispecies makes it difficult to ascertain the true nature of the original antigenic stimulus. To overcome this limitation, we evaluated the extent of CD8 T cell cross-reactivity in patients with acute HIV-1 clade B infection. In each case, we determined the transmitted founder virus… CONTINUE READING
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