HIV-1 Single-Stranded RNA Induces CXCL13 Secretion in Human Monocytes via TLR7 Activation and Plasmacytoid Dendritic Cell–Derived Type I IFN

@article{Cohen2015HIV1SR,
  title={HIV-1 Single-Stranded RNA Induces CXCL13 Secretion in Human Monocytes via TLR7 Activation and Plasmacytoid Dendritic Cell–Derived Type I IFN},
  author={K. Cohen and Anne Sophie Dugast and G. Alter and M. McElrath and L. Stamatatos},
  journal={The Journal of Immunology},
  year={2015},
  volume={194},
  pages={2769 - 2775}
}
  • K. Cohen, Anne Sophie Dugast, +2 authors L. Stamatatos
  • Published 2015
  • Biology, Medicine
  • The Journal of Immunology
  • Elevated levels of the chemokine CXCL13 have been observed in the plasma of chronically HIV-1–infected subjects and have been correlated with plasma viremia, which in turn has been linked to progressive dysregulation of humoral responses. In this study we sought to identify mechanisms of CXCL13 induction in response to HIV-1 infection. Plasma levels of CXCL13 in HIV-1–infected antiretroviral therapy–naive subjects correlated with viral load and were higher compared with antiretroviral therapy… CONTINUE READING
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