HIV-1 Selection by Epidermal Dendritic Cells during Transmission across Human Skin

@article{Reece1998HIV1SB,
  title={HIV-1 Selection by Epidermal Dendritic Cells during Transmission across Human Skin },
  author={Jeanette C. Reece and Amanda J. Handley and E. John Anstee and Wayne A. Morrison and Suzanne M. Crowe and Paul U Cameron},
  journal={The Journal of Experimental Medicine},
  year={1998},
  volume={187},
  pages={1623 - 1631}
}
Macrophage tropic HIV-1 is predominant during the initial viremia after person to person transmission of HIV-1 (Zhu, T., H. Mo, N. Wang, D.S. Nam, Y. Cao, R.A. Koup, and D.D. Ho. 1993. Science. 261:1179-1181.), and this selection may occur during virus entry and carriage to the lymphoid tissue. Human skin explants were used to model HIV-1 selection that may occur at the skin or mucosal surface. Macrophage tropic, but not T cell line tropic strains of HIV-1 applied to the abraded epidermis were… CONTINUE READING