HIV-1 Protease and Reverse Transcriptase Control the Architecture of Their Nucleocapsid Partner

Abstract

The HIV-1 nucleocapsid is formed during protease (PR)-directed viral maturation, and is transformed into pre-integration complexes following reverse transcription in the cytoplasm of the infected cell. Here, we report a detailed transmission electron microscopy analysis of the impact of HIV-1 PR and reverse transcriptase (RT) on nucleocapsid plasticity… (More)

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6 Figures and Tables