HIV-1 Neutralizing Antibodies with Limited Hypermutation from an Infant

@article{Simonich2016HIV1NA,
  title={HIV-1 Neutralizing Antibodies with Limited Hypermutation from an Infant},
  author={Cassandra A. Simonich and Katherine Lee Williams and Hans P. Verkerke and James A Williams and Ruth Nduati and Kelly K. Lee and Julie M Overbaugh},
  journal={Cell},
  year={2016},
  volume={166},
  pages={77-87}
}
HIV-1 broadly neutralizing antibodies (bnAbs) develop in a subset of infected adults and exhibit high levels of somatic hypermutation (SHM) due to years of affinity maturation. There is no precedent for eliciting highly mutated antibodies by vaccination, nor is it practical to wait years for a desired response. Infants develop broad responses early, which may suggest a more direct path to generating bnAbs. Here, we isolated ten neutralizing antibodies (nAbs) contributing to plasma breadth of an… CONTINUE READING