HIV-1 Nef protein protects infected primary cells against killing by cytotoxic T lymphocytes

@article{Collins1998HIV1NP,
  title={HIV-1 Nef protein protects infected primary cells against killing by cytotoxic T lymphocytes},
  author={Kathleen L Collins and Benjamin K Chen and Spyros A. Kalams and Bruce D. Walker and David Baltimore},
  journal={Nature},
  year={1998},
  volume={391},
  pages={397-401}
}
Cytotoxic T lymphocytes (CTLs) lyse virally infected cells that display viral peptide epitopes in association with major histocompatibility complex (MHC) class I molecules on the cell surface. However, despite a strong CTL response directed against viral epitopes, untreated people infected with the human immunodeficiency virus (HIV-1) develop AIDS. To resolve this enigma, we have examined the ability of CTLs to recognize and kill infected primary T lymphocytes. We found that CTLs inefficiently… CONTINUE READING

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