HIV-1 Nef induces a Rab11-dependent routing of endocytosed immune costimulatory proteins CD80 and CD86 to the Golgi.

@article{Chaudhry2008HIV1NI,
  title={HIV-1 Nef induces a Rab11-dependent routing of endocytosed immune costimulatory proteins CD80 and CD86 to the Golgi.},
  author={Ashutosh Chaudhry and Suman R Das and Shahid Jameel and Anna George and Vineeta Bal and Satyajit Mayor and Satyajit Rath},
  journal={Traffic},
  year={2008},
  volume={9 11},
  pages={1925-35}
}
The Nef protein of HIV-1 removes the immune costimulatory proteins CD80 and CD86 from the cell surface by a unique clathrin- and dynamin-independent, actin-based endocytic pathway that deploys coupled activation of c-src and Rac. In this study, we show that, similar to major histocompatibility complex class I (MHCI), Nef subsequently reroutes CD80 and CD86 to the Golgi region. However, not only are CD80/CD86 internalized by a different mechanism from MHCI but also the vesicular pathway of Golgi… CONTINUE READING

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