HIV-1 Nef-induced cardiotoxicity through dysregulation of autophagy

  title={HIV-1 Nef-induced cardiotoxicity through dysregulation of autophagy},
  author={Manish K. Gupta and Raffael Kaminski and Brian Mullen and Jennifer Gordon and Tricia H. Burdo and Joseph Y Cheung and Arthur M Feldman and Muniswamy Madesh and Kamel Khalili},
  booktitle={Scientific Reports},
Cardiovascular disease is a leading cause of co-morbidity in HIV-1 positive patients, even those in whom plasma virus levels are well-controlled. The pathogenic mechanism of HIV-1-associated cardiomyopathy is unknown, but has been presumed to be mediated indirectly, owing to the absence of productive HIV-1 replication in cardiomyocytes. We sought to investigate the effect of the HIV-1 auxiliary protein, Nef, which is suspected of extracellular release by infected CD4+ T cells on protein quality… CONTINUE READING
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