HIV-1 Nef-induced cardiotoxicity through dysregulation of autophagy

@inproceedings{Gupta2017HIV1NC,
  title={HIV-1 Nef-induced cardiotoxicity through dysregulation of autophagy},
  author={Manish K. Gupta and Raffael Kaminski and Brian Mullen and Jennifer Gordon and Tricia H. Burdo and Joseph Y Cheung and Arthur M Feldman and Muniswamy Madesh and Kamel Khalili},
  booktitle={Scientific Reports},
  year={2017}
}
Cardiovascular disease is a leading cause of co-morbidity in HIV-1 positive patients, even those in whom plasma virus levels are well-controlled. The pathogenic mechanism of HIV-1-associated cardiomyopathy is unknown, but has been presumed to be mediated indirectly, owing to the absence of productive HIV-1 replication in cardiomyocytes. We sought to investigate the effect of the HIV-1 auxiliary protein, Nef, which is suspected of extracellular release by infected CD4+ T cells on protein quality… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 2 times over the past 90 days. VIEW TWEETS
2 Citations
73 References
Similar Papers

Citations

Publications citing this paper.

References

Publications referenced by this paper.
Showing 1-10 of 73 references

Elimination of HIV-1 Genomes from Human T-lymphoid Cells by CRISPR/Cas9 Gene Editing

  • R Kaminski
  • Sci Rep
  • 2016

Similar Papers

Loading similar papers…