HIV-1 Nef down-regulates the hemochromatosis protein HFE, manipulating cellular iron homeostasis.

@article{Drakesmith2005HIV1ND,
  title={HIV-1 Nef down-regulates the hemochromatosis protein HFE, manipulating cellular iron homeostasis.},
  author={Hal Drakesmith and Nan Chen and Hannah Ledermann and Gavin Robert Screaton and Alain Townsend and Xiao-ning Xu},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2005},
  volume={102 31},
  pages={11017-22}
}
The multifunctional Nef protein of HIV-1 is important for the progression to AIDS. One action of Nef is to down-regulate surface MHC I molecules, helping infected cells to evade immunity. We found that Nef also down-regulates the macrophage-expressed MHC 1b protein HFE, which regulates iron homeostasis and is mutated in the iron-overloading disorder hemochromatosis. In model cell lines, Nef reroutes HFE to a perinuclear structure that overlaps the trans-Golgi network, causing a 90% reduction of… CONTINUE READING
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