HIV-1 Nef dimerization is required for Nef-mediated receptor downregulation and viral replication.

@article{Poe2009HIV1ND,
  title={HIV-1 Nef dimerization is required for Nef-mediated receptor downregulation and viral replication.},
  author={Jerrod A. Poe and Thomas E Smithgall},
  journal={Journal of molecular biology},
  year={2009},
  volume={394 2},
  pages={
          329-42
        }
}
Nef, a human immunodeficiency virus type 1 (HIV-1) accessory factor capable of interaction with a diverse array of host cell signaling molecules, is essential for high-titer HIV replication and AIDS progression. Previous biochemical and structural studies have suggested that Nef may form homodimers and higher-order oligomers in HIV-infected cells, which may be required for both immune and viral receptor downregulation as well as viral replication. Using bimolecular fluorescence complementation… CONTINUE READING
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