HIV-1 Nef control of cell signalling molecules: Multiple strategies to promote virus replication

@article{Greenway2008HIV1NC,
  title={HIV-1 Nef control of cell signalling molecules: Multiple strategies to promote virus replication},
  author={A. Greenway and G. Holloway and D. McPhee and P. Ellis and A. Cornall and Michael Lidman},
  journal={Journal of Biosciences},
  year={2008},
  volume={28},
  pages={323-335}
}
  • A. Greenway, G. Holloway, +3 authors Michael Lidman
  • Published 2008
  • Biology, Medicine
  • Journal of Biosciences
  • HIV-1 has at its disposal numerous proteins encoded by its genome which provide the required arsenal to establish and maintain infection in its host for a considerable number of years. One of the most important and enigmatic of these proteins is Nef. The Nef protein of HIV-1 plays a fundamental role in the virus life cycle. This small protein of approximately 27 kDa is required for maximal virus replication and disease progression. The mechanisms by which it is able to act as a positive factor… CONTINUE READING
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