HIV-1 Nef and Vpu are functionally redundant broad-spectrum modulators of cell surface receptors, including tetraspanins.

@article{Haller2014HIV1NA,
  title={HIV-1 Nef and Vpu are functionally redundant broad-spectrum modulators of cell surface receptors, including tetraspanins.},
  author={Claudia M Haller and Birthe Mueller and Jo{\"e}lle V. Fritz and Miguel Lamas-Murua and Bettina Stolp and François M Pujol and Oliver T. Keppler and Oliver T. Fackler},
  journal={Journal of virology},
  year={2014},
  volume={88 24},
  pages={14241-57}
}
UNLABELLED HIV-1 Nef and Vpu are thought to optimize virus replication in the infected host, at least in part via their ability to interfere with vesicular host cell trafficking. Despite the use of distinct molecular mechanisms, Nef and Vpu share specificity for some molecules such as CD4 and major histocompatibility complex class I (MHC-I), while disruption of intracellular transport of the host cell restriction factor CD317/tetherin represents a specialized activity of Vpu not exerted by HIV… CONTINUE READING
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HIV-1 down-regulates the expression of CD1d via Nef.

European journal of immunology • 2006
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