HIV-1 Nef and KSHV oncogene K1 synergistically promote angiogenesis by inducing cellular miR-718 to regulate the PTEN/AKT/mTOR signaling pathway

@inproceedings{Xue2014HIV1NA,
  title={HIV-1 Nef and KSHV oncogene K1 synergistically promote angiogenesis by inducing cellular miR-718 to regulate the PTEN/AKT/mTOR signaling pathway},
  author={Min Xue and Shuihong Yao and Minmin Hu and Wan Li and Tingting Hao and Feng Zhou and Xiaofei Zhu and Hongmei Lu and Di Qin and Qin Yan and Jianzhong Zhu and Shou-Jiang Gao and Chun Tai Lu},
  booktitle={Nucleic acids research},
  year={2014}
}
Kaposi's sarcoma (KS) is an AIDS-defining cancer with aberrant neovascularization caused by KS-associated herpesvirus (KSHV). Although the interaction between HIV-1 and KSHV plays a pivotal role in promoting the aggressive manifestations of KS, the pathogenesis underlying AIDS-KS remains largely unknown. Here we examined HIV-1 Nef protein promotion of KSHV oncoprotein K1-induced angiogenesis. We showed that both internalized and ectopic expression of Nef in endothelial cells synergized with K1… CONTINUE READING
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