HIV-1 IN strand transfer chelating inhibitors: a focus on metal binding.

  title={HIV-1 IN strand transfer chelating inhibitors: a focus on metal binding.},
  author={Alessia Bacchi and Mauro Carcelli and Carlotta Compari and Emilia Fisicaro and Nicolino Pala and Gabriele Rispoli and Dominga Rogolino and Tino Wilson Sanchez and Mario Sechi and Nouri Neamati},
  journal={Molecular pharmaceutics},
  volume={8 2},
Most active and selective strand transfer HIV-1 integrase (IN) inhibitors contain chelating functional groups that are crucial feature for the inhibition of the catalytic activities of the enzyme. In particular, diketo acids and their derivatives can coordinate one or two metal ions within the catalytic core of the enzyme. The present work is intended as a contribution to elucidate the mechanism of action of the HIV-IN inhibitors by studying the coordinative features of H₂L¹ (L-708,906), an… CONTINUE READING

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