HIV-1 Exploits the Host Factor RuvB-like 2 to Balance Viral Protein Expression.

@article{Mu2015HIV1ET,
  title={HIV-1 Exploits the Host Factor RuvB-like 2 to Balance Viral Protein Expression.},
  author={Xin Yi Mu and Yajing Fu and Yiping Zhu and Xinlu Wang and Yifang Xuan and Hong Shang and Stephen P Goff and Guangxia Gao},
  journal={Cell host & microbe},
  year={2015},
  volume={18 2},
  pages={233-42}
}
The correct ratio of the HIV-1 structural protein Gag to the envelope protein (Env) is important for maximal virion infectivity. How the virus ensures the production of Gag and Env proteins in an appropriate ratio remains unknown. We report that HIV-1 exploits the host factor RuvB-like 2 (RVB2) to balance relative expression of Gag and Env for efficient production of infectious virions. RVB2 inhibits Gag expression by interacting with both the encoded Matrix (MA) domain of Gag protein and 5… CONTINUE READING