HIV-1 Escape From RNAi Antivirals: Yet Another Houdini Action?

To the Editor: Since the identification of HIV-1 as the primary cause of AIDS, much effort has been made to develop therapies that potently inhibit virus replication. Unfortunately, HIV-1 uses an error-prone replication machinery that allows the virus to rapidly adapt to new conditions. As a consequence , early single-drug therapies failed because of the… CONTINUE READING