HIV-1 Adaptation to Antigen Processing Results in Population-Level Immune Evasion and Affects Subtype Diversification

@inproceedings{Tenzer2014HIV1AT,
  title={HIV-1 Adaptation to Antigen Processing Results in Population-Level Immune Evasion and Affects Subtype Diversification},
  author={Stefan Tenzer and Hayley Crawford and Phillip Pymm and Robert Gifford and Vattipally B. Sreenu and Mirjana Weimershaus and Tulio de Oliveira and Anne Burgevin and Jan Gerstoft and Nadja Akkad and Daniel Lunn and Lars Fugger and J. Bell and Hansjoerg Schild and Peter van Endert and Astrid K. N. Iversen},
  booktitle={Cell reports},
  year={2014}
}
The recent HIV-1 vaccine failures highlight the need to better understand virus-host interactions. One key question is why CD8(+) T cell responses to two HIV-Gag regions are uniquely associated with delayed disease progression only in patients expressing a few rare HLA class I variants when these regions encode epitopes presented by ~30 more common HLA variants. By combining epitope processing and computational analyses of the two HIV subtypes responsible for ~60% of worldwide infections, we… CONTINUE READING
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