HIV-1–induced AIDS in monkeys

  title={HIV-1–induced AIDS in monkeys},
  author={Theodora Hatziioannou and Gregory Q. del Prete and Brandon F Keele and Jacob D Estes and Matthew W. McNatt and Julia Bitzegeio and Alice Raymond and Anthony Rodriguez and Fabian Schmidt and Charles Mac Trubey and Jeremy Smedley and Michael J. Piatak and Vineet N Kewalramani and Jeffrey D Lifson and Paul D Bieniasz},
Primate lentiviruses exhibit narrow host tropism, reducing the occurrence of zoonoses but also impairing the development of optimal animal models of AIDS. To delineate the factors limiting cross-species HIV-1 transmission, we passaged a modified HIV-1 in pigtailed macaques that were transiently depleted of CD8+ cells during acute infection. During adaptation over four passages in macaques, HIV-1 acquired the ability to antagonize the macaque restriction factor tetherin, replicated at… CONTINUE READING
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A, Ala; C, Cys; D, Asp; E, Glu; F, Phe; G, Gly; H, His; I, Ile; K, Lys; L, Leu; M, Met; N, Asn; P, Pro; Q, Gln; R, Arg; S, Ser; T, Thr; V, Val; W, Trp; and Y, Tyr

  • Single-letter abbreviations for the amino acid residues are as follows
  • ACKNOWLEDGMENTS The data presented in this paper…
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