HIV-1: Cofactors provide the entry keys

@article{Wilkinson1996HIV1CP,
  title={HIV-1: Cofactors provide the entry keys},
  author={David Wilkinson},
  journal={Current Biology},
  year={1996},
  volume={6},
  pages={1051-1053}
}
  • D. Wilkinson
  • Published 1 September 1996
  • Physics
  • Current Biology

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The principal cofactor for entry mediated by the envelope glycoproteins of primary macrophage-tropic strains of HIV-1 is CC-CKR-5, a receptor for the β-chemokines RANTES, Mip-1α and MIP-1β.
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A 20-amino acid sequence from the macrophage-tropic BaL isolate of HIV-1 was sufficient to confermacrophage tropism on HTLV-IIIB, a T cell line--tropic isolate, and this small sequence element is in the V3 loop, the envelope domain that is the principal neutralizing determinant of HIV -1.
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