HIV-1: Cofactors provide the entry keys

@article{Wilkinson1996HIV1CP,
  title={HIV-1: Cofactors provide the entry keys},
  author={David Wilkinson},
  journal={Current Biology},
  year={1996},
  volume={6},
  pages={1051-1053}
}
  • D. Wilkinson
  • Published 1 September 1996
  • Physics
  • Current Biology
View on Elsevier
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References

SHOWING 1-10 OF 30 REFERENCES
Identification of a major co-receptor for primary isolates of HIV-1
TLDR
The principal cofactor for entry mediated by the envelope glycoproteins of primary macrophage-tropic strains of HIV-1 is CC-CKR-5, a receptor for the β-chemokines RANTES, Mip-1α and MIP-1β.
Identification of the envelope V3 loop as the primary determinant of cell tropism in HIV-1.
TLDR
A 20-amino acid sequence from the macrophage-tropic BaL isolate of HIV-1 was sufficient to confermacrophage tropism on HTLV-IIIB, a T cell line--tropic isolate, and this small sequence element is in the V3 loop, the envelope domain that is the principal neutralizing determinant of HIV -1.
HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5
The β-chemokines MIP-1α, MIP-1β and RANTES inhibit infection of CD4+ cells by primary, non-syncytium-inducing (NSI) HIV-1 strains at the virus entry stage, and also block env-mediated cell–cell…
The β-Chemokine Receptors CCR3 and CCR5 Facilitate Infection by Primary HIV-1 Isolates
Homozygous Defect in HIV-1 Coreceptor Accounts for Resistance of Some Multiply-Exposed Individuals to HIV-1 Infection
HIV-1 Entry Cofactor: Functional cDNA Cloning of a Seven-Transmembrane, G Protein-Coupled Receptor
TLDR
A cofactor for HIV-1 (human immunodeficiency virus-type 1) fusion and entry was identified with the use of a novel functional complementary DNA (cDNA) cloning strategy that is a putative G protein-coupled receptor with seven transmembrane segments.
CC CKR5: A RANTES, MIP-1α, MIP-1ॆ Receptor as a Fusion Cofactor for Macrophage-Tropic HIV-1
TLDR
Recombinant CC CKR5, a G protein-coupled receptor for these chemokines, rendered CD4-expressing nonhuman cells fusion-competent preferentially with macrophage-tropic Envs, and is thus a fusion cofactor for HIV-1 strains.
Conformational changes induced in the envelope glycoproteins of the human and simian immunodeficiency viruses by soluble receptor binding
TLDR
The use of a soluble form of CD4 as a receptor mimic demonstrates that receptor binding to the outer envelope glycoprotein induces certain conformational changes which are common to all of these viruses and others which are restricted to cell line-passaged isolates of HIV-1.
Cofactor requirement for human immunodeficiency virus type 1 entry into a CD4-expressing human cell line
TLDR
Results suggest that HeLa cells express a factor(s) that can complement the viral entry defect of U373-CD4 cells and is necessary for efficient CD4-mediated HIV-1 infection.
Resistance to HIV-1 infection in Caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene
TLDR
It is shown that a mutant allele of CCR-5 is present at a high frequency in caucasian populations, but is absent in black populations from Western and Central Africa and Japanese populations, and a 32-base-pair deletion within the coding region results in a frame shift, and generates a non-functional receptor that does not support membrane fusion or infection by macrophage- and dual-tropic HIV-1 strains.
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