HIV-1/AIDS susceptibility and copy number variation in CCL3L1, a gene encoding a natural ligand for HIV-1 co-receptor CCR5.

@article{Nakajima2008HIV1AIDSSA,
  title={HIV-1/AIDS susceptibility and copy number variation in CCL3L1, a gene encoding a natural ligand for HIV-1 co-receptor CCR5.},
  author={Toshiaki Nakajima and Gunisha Kaur and Narinder K Mehra and Akihisa Kimura},
  journal={Cytogenetic and genome research},
  year={2008},
  volume={123 1-4},
  pages={156-60}
}
Variations of gene copy number in the human genome are increasingly recognized as a genetic factor in phenotypic variation. Human CC chemokine ligand 3-like 1 gene (CCL3L1), which is located on human chromosome 17q11.2, is highly variable in copy number owing to having a hot spot for segmental duplications. CCL3L1, a natural ligand for HIV-1 co-receptor CCR5, is a potent HIV-1-suppressive chemokine. CCL3L1 copy number variation (CNV) is tightly linked to HIV-1/AIDS susceptibility, and a lower… CONTINUE READING
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CCL 3 L 1 and CCL 4 L 1 : variable gene copy number in adolescents with and without human immunodeficiency virus type 1 ( HIV - 1 ) infection

  • W Shao, J Tang, W Song, C Wang, Y Li
  • Genes Immun
  • 2007
Highly Influential
4 Excerpts

Host CCL 3 L 1 gene copy number in relation to HIV - 1 - specific CD 4 + and CD 8 + T - cell responses and viral load in South African women

  • S Shalekoff, S Meddows-Taylor, DB Schramm, SL Donninger, GE Gray
  • J Acquir Immune Defic Syndr
  • 2008
1 Excerpt

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