HIV‐1 protease inhibitor induces growth arrest and apoptosis of human prostate cancer LNCaP cells in vitro and in vivo in conjunction with blockade of androgen receptor STAT3 and AKT signaling

@article{Yang2005HIV1PI,
  title={HIV‐1 protease inhibitor induces growth arrest and apoptosis of human prostate cancer LNCaP cells in vitro and in vivo in conjunction with blockade of androgen receptor STAT3 and AKT signaling},
  author={Yang Yang and Takayuki Ikezoe and Tamotsu Takeuchi and Yoshihiro Adachi and Yuji Ohtsuki and Seisho Takeuchi and H. Phillip Koeffler and Hirokuni Taguchi},
  journal={Cancer Science},
  year={2005},
  volume={96}
}
This study found that the HIV‐1 protease inhibitor nelfinavir (NFV) induced growth arrest and apoptosis of human prostate cancer cells (LNCaP, DU145 and PC‐3 cells), as measured by MTT and terminal deoxyribonucleotide transferase‐mediated dUTP nick end labeling (TUNEL) assays, respectively, on the third day of culture. In addition, NFV blocked androgen receptor (AR) signaling in association with downregulation of nuclear levels of AR in LNCaP cells as measured by reporter assay and western blot… Expand
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