HIV‐1 protease inhibitor induces growth arrest and apoptosis of human prostate cancer LNCaP cells in vitro and in vivo in conjunction with blockade of androgen receptor STAT3 and AKT signaling

@article{Yang2005HIV1PI,
  title={HIV‐1 protease inhibitor induces growth arrest and apoptosis of human prostate cancer LNCaP cells in vitro and in vivo in conjunction with blockade of androgen receptor STAT3 and AKT signaling},
  author={Yang Yang and Takayuki Ikezoe and Tamotsu Takeuchi and Yoshihiro Adachi and Yuji Ohtsuki and Seisho Takeuchi and H. Phillip Koeffler and Hirokuni Taguchi},
  journal={Cancer Science},
  year={2005},
  volume={96}
}
This study found that the HIV‐1 protease inhibitor nelfinavir (NFV) induced growth arrest and apoptosis of human prostate cancer cells (LNCaP, DU145 and PC‐3 cells), as measured by MTT and terminal deoxyribonucleotide transferase‐mediated dUTP nick end labeling (TUNEL) assays, respectively, on the third day of culture. In addition, NFV blocked androgen receptor (AR) signaling in association with downregulation of nuclear levels of AR in LNCaP cells as measured by reporter assay and western blot… 

Human immunodeficiency virus protease inhibitors reduce the growth of human tumors via a proteasome‐independent block of angiogenesis and matrix metalloproteinases

Indinavir and saquinavir significantly inhibited the growth of all adenocarcinomas tested in the mice model, suggesting that HIV‐PIs or their analogues, characterized by a better biodistribution and lower toxicity, may represent a new class of antitumor drugs capable of targeting both matrix metalloproteinases and the proteasome for a most effective antitumors therapy.

Effect of SU11248 on gastrointestinal stromal tumor‐T1 cells: Enhancement of growth inhibition via inhibition of 3‐kinase/Akt/mammalian target of rapamycin signaling

Clinical studies of SU11248 for individuals with GIST are supported, and the combination of SU 11248 and inhibitors of 3‐kinase/Akt/mammalian target of rapamycin signaling represents a promising novel treatment strategy.

Nelfinavir inhibits regulated intramembrane proteolysis of sterol regulatory element binding protein‐1 and activating transcription factor 6 in castration‐resistant prostate cancer

S2P is validates S2P as a therapeutic target in castration‐resistant prostate cancer and provides new insights into nelfinavir‐induced endoplasmic reticulum stress and cancer cell death, and is proposed for investigating its clinical activity in castrated prostate cancer.

The human immunodeficiency virus-1 protease inhibitor nelfinavir impairs proteasome activity and inhibits the proliferation of multiple myeloma cells in vitro and in vivo

Nelfinavir enhanced the anti-proliferative activity of bortezomib, dexamethasone and histone deacetylase inhibitors and delayed tumor growth in a myeloma mouse model, suggesting that nelfinavIR, used at a pharmacological dosage, alone or in combination, may be useful in the treatment of Myeloma.

ZD6474 induces growth arrest and apoptosis of GIST‐T1 cells, which is enhanced by concomitant use of sunitinib

ZD6474 induced growth arrest and apoptosis of GIST‐T1 cells in association with blockade of c‐Kit and its downstream effectors, including Akt and extracellular signal‐regulated kinase (ERK).

Radiosensitization of Epidermal Growth Factor Receptor/HER2–Positive Pancreatic Cancer Is Mediated by Inhibition of Akt Independent of Ras Mutational Status

Inhibition of EGFR/HER2 enhances radiosensitivity in wild-type K-ras pancreatic cancer, and nelfinavir, and other phosphoinositide 3-kinase/Akt inhibitors, are effective pancreatic radiosensitizers regardless ofK-ras mutation status.

IL-6 and PPARγ Signalling in Human PC-3 Prostate Cancer Cells

The natural PPARγ ligand, 15deoxy Δ12-14 PGJ 2 (15dPGJ 2), and IL-6 were used to define their interactions on proliferation and signal transduction in PC-3 cells to study the effects of these ligands on prostate cancer cell proliferation and survival.
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