HIV: early virus-cell interactions.

  title={HIV: early virus-cell interactions.},
  author={Claus Grewe and Alain Beck and Hans R. Gelderblom},
  journal={Journal of acquired immune deficiency syndromes},
  volume={3 10},
Two entry mechanisms of HIV occur in both lymphocytes and macrophages incubated with purified virus suspensions: (a) direct fusion of the viral envelope with the cell membrane and (b) receptor-mediated endocytosis via clathrin-coated pits and vesicles. Both mechanisms are shown in detail in a time-interval series of electron micrographs. The two lipid bilayers of the viral envelope and of the cellular membrane usually fuse seamlessly within 1-3 min at 37 degrees C, but occasionally membrane… CONTINUE READING
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