HIV/AIDS vaccines: a need for new concepts?

  title={HIV/AIDS vaccines: a need for new concepts?},
  author={Marc P Girard and Geetha P. Bansal},
  journal={International reviews of immunology},
  volume={27 6},
HIV vaccine research is at a crossroads carefully contemplating on the next path. The unexpected results of the Merck vaccine trial, while providing a stunning blow to a field in dire need of a protective vaccine, has also raised several fundamental questions regarding the candidate immunogen itself, preexisting immunity to vaccine vectors, surrogate assays and animal models used for assessing preclinical protective responses, as well as relevant endpoints to be measured in a clinical trial. As… CONTINUE READING

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