HIV, transmitted drug resistance, and the paradox of preexposure prophylaxis.

  title={HIV, transmitted drug resistance, and the paradox of preexposure prophylaxis.},
  author={Virginie Supervie and Jos{\'e} Gerardo Garc{\'i}a-Lerma and Walid Heneine and Sally Blower},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={107 27},
The administration of antiretrovirals before HIV exposure to prevent infection (i.e., preexposure prophylaxis; PrEP) is under evaluation in clinical trials. Because PrEP is based on antiretrovirals, there is considerable concern that it could substantially increase transmitted resistance, particularly in resource-rich countries. Here we use a mathematical model to predict the effect of PrEP interventions on the HIV epidemic in the men-who-have-sex-with-men community in San Francisco. The model… CONTINUE READING
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