HIT paradigms and paradoxes

  title={HIT paradigms and paradoxes},
  author={Theodore E Warkentin},
  journal={Journal of thrombosis and haemostasis : JTH},
  volume={9 Suppl 1},
The current major problem with HIT is its overdiagnosis. This concept follows from the HIT central paradigm: HIT is caused by a subset of antibodies against platelet factor 4 (PF4)/heparin complexes that have strong platelet-activating properties. Prospective studies show that only a minority of sera containing such antibodies exhibit platelet-activating properties. Ironically, the earliest tests for HIT--platelet activation assays--remain today the most diagnostically useful, particularly the… CONTINUE READING


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