HIRA is essential for the development of gibel carp

  title={HIRA is essential for the development of gibel carp},
  author={Meng-yu Wang and Q Guo and Xin-Zheng Du and Li Zhou and Qian Luo and Qiao-Hui Zeng and Jia-lin Wang and Hao-bin Zhao and Yu-feng Wang},
  journal={Fish Physiology and Biochemistry},
HIRA is one of the chaperones of histone H3.3. Mutation of Hira results in embryonic lethality in mice, suggesting a critical role in embryogenesis. However, Hira-mutated Drosophila may survive to adults, indicating that it is dispensable in Drosophila development. The role of Hira in fish development is unknown. In this study we first investigated the expression of Hira during embryogenesis of gibel carp (Carassius auratus gibelio) by whole-mount in situ hybridization. We found that Hira… CONTINUE READING
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