HIPK2 modulates p53 activity towards pro-apoptotic transcription

  title={HIPK2 modulates p53 activity towards pro-apoptotic transcription},
  author={Rosa Puca and Lavinia Nardinocchi and Ada Sacchi and Gideon Rechavi and David Givol and G D'orazi},
  journal={Molecular Cancer},
  pages={85 - 85}
Activation of p53-mediated gene transcription is a critical cellular response to DNA damage and involves a phosphorylation-acetylation cascade of p53. The discovery of differences in the response to different agents raises the question whether some of the p53 oncosuppressor functions might be exerted by different posttranslational modifications. Stress-induced homeodomain-interacting protein kinase-2 (HIPK2) phosphorylates p53 at serine-46 (Ser46) for p53 apoptotic activity; p53 acetylation at… CONTINUE READING
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