HIP-I: a huntingtin interacting protein isolated by the yeast two-hybrid system.

@article{Wanker1997HIPIAH,
  title={HIP-I: a huntingtin interacting protein isolated by the yeast two-hybrid system.},
  author={Erich E. Wanker and Charles-A. Rovira and Eberhard Scherzinger and Renate Hasenbank and Stephanie Waelter and D Tait and John J. Colicelli and Hans Lehrach},
  journal={Human molecular genetics},
  year={1997},
  volume={6 3},
  pages={
          487-95
        }
}
We report the discovery of the huntingtin interacting protein I (HIP-I) which binds specifically to the N-terminus of human huntingtin, both in the two-hybrid screen and in in vitro binding experiments. For the interaction in vivo, a protein region downstream of the polyglutamine stretch in huntingtin is essential. The HIP1 cDNA isolated by the two-hybrid screen encodes a 55 kDa fragment of a novel protein. Using an affinity-purified polyclonal antibody raised against recombinant HIP-I, a… CONTINUE READING

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