HIP-55 is important for T-cell proliferation, cytokine production, and immune responses.

@article{Han2005HIP55II,
  title={HIP-55 is important for T-cell proliferation, cytokine production, and immune responses.},
  author={Jin Han and Jr-Wen Shui and Xuejun Zhang and Biao Zheng and Shuhua Han and Tse-Hua Tan},
  journal={Molecular and cellular biology},
  year={2005},
  volume={25 16},
  pages={6869-78}
}
Engagement of the T-cell receptor (TCR) triggers a series of signaling events that lead to the activation of T cells. HIP-55 (SH3P7 or mAbp1), an actin-binding adaptor protein, interacts with and is tyrosine phosphorylated by ZAP-70, which is a crucial proximal protein tyrosine kinase for TCR signaling. HIP-55 is important for JNK and HPK1 activation induced by TCR signaling. In this study, we report the generation and characterization of HIP-55 knockout mice. We found that HIP-55 knockout mice… CONTINUE READING