HIP-55 Is Important for T-Cell Proliferation, Cytokine Production, and Immune Responses

@article{Han2005HIP55II,
  title={HIP-55 Is Important for T-Cell Proliferation, Cytokine Production, and Immune Responses},
  author={Jin Seok Han and Jr-Wen Shui and Xuejun Zhang and Biao Zheng and Shuhua Han and Tse-Hua Tan},
  journal={Molecular and Cellular Biology},
  year={2005},
  volume={25},
  pages={6869 - 6878}
}
  • Jin Seok Han, Jr-Wen Shui, +3 authors Tse-Hua Tan
  • Published 2005
  • Biology, Medicine
  • Molecular and Cellular Biology
  • ABSTRACT Engagement of the T-cell receptor (TCR) triggers a series of signaling events that lead to the activation of T cells. HIP-55 (SH3P7 or mAbp1), an actin-binding adaptor protein, interacts with and is tyrosine phosphorylated by ZAP-70, which is a crucial proximal protein tyrosine kinase for TCR signaling. HIP-55 is important for JNK and HPK1 activation induced by TCR signaling. In this study, we report the generation and characterization of HIP-55 knockout mice. We found that HIP-55… CONTINUE READING

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