HIN-200 proteins regulate caspase activation in response to foreign cytoplasmic DNA.

Abstract

The mammalian innate immune system is activated by foreign nucleic acids. Detection of double-stranded DNA (dsDNA) in the cytoplasm triggers characteristic antiviral responses and macrophage cell death. Cytoplasmic dsDNA rapidly activated caspase 3 and caspase 1 in bone marrow-derived macrophages. We identified the HIN-200 family member and candidate lupus… (More)
DOI: 10.1126/science.1169841

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