HIGH FAT DIET INDUCES LUNG REMODELING IN APOE DEFICIENT MICE: AN ASSOCIATION WITH AN INCREASE IN CIRCULATORY AND LUNG INFLAMMATORY FACTORS

@inproceedings{Naura2009HIGHFD,
  title={HIGH FAT DIET INDUCES LUNG REMODELING IN APOE DEFICIENT MICE: AN ASSOCIATION WITH AN INCREASE IN CIRCULATORY AND LUNG INFLAMMATORY FACTORS},
  author={Amarjit S Naura and Chetan P Hans and Mourad Zerfaoui and Youssef Errami and Jihang Ju and Hogyoung Kim and Khalid Matrougui and Jong Geal Kim and A Hamid Boulares},
  booktitle={Laboratory Investigation},
  year={2009}
}
Hypercholesterolemia is increasingly considered the basis for not only cardiovascular pathologies but also several complications affecting other organs such as lungs. In this study, we examined the effect of hypercholesterolemia on lung integrity using a mouse model (ApoE−/−) of high-fat (HF) diet-induced atherosclerosis. A 12-week HF diet regimen induced systemic production of TNF-α, IFN-γ, GMC-SF, RANTES, IL-1α, IL-2 and IL-12 with TNF-α as the predominant cytokine in ApoE−/− mice… CONTINUE READING
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