HIGH ABSORPTION BUT VERY LOW BIOAVAILABILITY OF ORAL RESVERATROL IN HUMANS

@article{Walle2004HIGHAB,
  title={HIGH ABSORPTION BUT VERY LOW BIOAVAILABILITY OF ORAL RESVERATROL IN HUMANS},
  author={Thomas Walle and Faye Hsieh and Mark H. Delegge and John E. Oatis and U. Kristina Walle},
  journal={Drug Metabolism and Disposition},
  year={2004},
  volume={32},
  pages={1377 - 1382}
}
The dietary polyphenol resveratrol has been shown to have chemopreventive activity against cardiovascular disease and a variety of cancers in model systems, but it is not clear whether the drug reaches the proposed sites of action in vivo after oral ingestion, especially in humans. In this study, we examined the absorption, bioavailability, and metabolism of 14C-resveratrol after oral and i.v. doses in six human volunteers. The absorption of a dietary relevant 25-mg oral dose was at least 70… Expand

Paper Mentions

Interventional Clinical Trial
The Metabolic Syndrome is a high prevalence disease worldwide. About a quarter of the adult population suffers the disease. Resveratrol is a substance found in many plants… Expand
ConditionsMetabolic Syndrome X
InterventionDrug
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TLDR
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  • 2011
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Effect of food on the pharmacokinetic profile of trans-resveratrol.
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Distribution of [3H]trans-resveratrol in rat tissues following oral administration
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