HIGH ABSORPTION BUT VERY LOW BIOAVAILABILITY OF ORAL RESVERATROL IN HUMANS

@article{Walle2004HIGHAB,
  title={HIGH ABSORPTION BUT VERY LOW BIOAVAILABILITY OF ORAL RESVERATROL IN HUMANS},
  author={T. Walle and F. Hsieh and M. Delegge and J. Oatis and U. Walle},
  journal={Drug Metabolism and Disposition},
  year={2004},
  volume={32},
  pages={1377 - 1382}
}
  • T. Walle, F. Hsieh, +2 authors U. Walle
  • Published 2004
  • Medicine, Chemistry
  • Drug Metabolism and Disposition
  • The dietary polyphenol resveratrol has been shown to have chemopreventive activity against cardiovascular disease and a variety of cancers in model systems, but it is not clear whether the drug reaches the proposed sites of action in vivo after oral ingestion, especially in humans. In this study, we examined the absorption, bioavailability, and metabolism of 14C-resveratrol after oral and i.v. doses in six human volunteers. The absorption of a dietary relevant 25-mg oral dose was at least 70… CONTINUE READING

    Paper Mentions

    INTERVENTIONAL CLINICAL TRIAL
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