HIF2alpha cooperates with RAS to promote lung tumorigenesis in mice.

  title={HIF2alpha cooperates with RAS to promote lung tumorigenesis in mice.},
  author={William Y. Kim and Samanthi Perera and Bing Zhou and Juli{\'a}n Carretero and Jen Jen J. Yeh and Samuel A Heathcote and Autumn L Jackson and Petros Nikolinakos and Beatriz Ospina and George N. Naumov and Kathleyn A Brandstetter and Victor J. Weigman and Sara Zaghlul and D. Neil Hayes and Robert F Padera and John V. Heymach and Andrew L Kung and Norman E Sharpless and William G Kaelin and Kwok-kin Wong},
  journal={The Journal of clinical investigation},
  volume={119 8},
Members of the hypoxia-inducible factor (HIF) family of transcription factors regulate the cellular response to hypoxia. In non-small cell lung cancer (NSCLC), high HIF2alpha levels correlate with decreased overall survival, and inhibition of either the protein encoded by the canonical HIF target gene VEGF or VEGFR2 improves clinical outcomes. However, whether HIF2alpha is causal in imparting this poor prognosis is unknown. Here, we generated mice that conditionally express both a nondegradable… CONTINUE READING


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